Content: Each Prima-1000 soft gelatin capsule contains: Evening primrose oil 1000mg. Equivalent to active ingredients GLA (Gamma Linolenic Acid) 10%=100mg and LA (Linolenic acid)72%=720mg. Non-active ingredients & Preservative agent: DL-Alpha tocopherol (Vita-E)5mg.

Introduction: Evening primrose.Oenothera biennis is a perennial herb that takes it's name from it's unusual habitof opening it's flower between six and seven o'clock in evening. The plant is rich in an oil containingthe essential unsaturated fatty acid,gamma-Linolenic acid (GLA) of omega 6 series, is the precursorof prostaglandin E1

Mechanism of Action: The possible anti-inflammatory and anti-aggregatory actions of EPO may be accounted for byexamining the role of GLA in eicosanoid Biochemistry. GLA is metabolized to the 20-carbonpolyunsaturated fatty acid dihomo-gamma-linolenic acid (DGLA;20: 3n-6), which is a precursor to the1-series prostaglandins, such as prostaglandin E,, (PGE,). The action of PGE,, on inflammatory cells(e.g., polymorphonuclear leukocytes or PMNs) is mostly inhibitory.PGE,increases intracellular cyclicAMP (cAMP). This increase reduces the release of lysosomal enzymes, PMN chemotaxis and themargination and adherence of PMNs in the blood vessels. PGE,, is also thought to inhibit lymphocytefunction. PGE,, in addition to its role in suppressing the inflammatory process,inhibits plateletaggregation and has vasodilatory activity. GLA, via its metabolite DGLA, has an inhibitory effect onleukotriene (LT) synthesis. Leukotrlene B4(LTB4) is an inflammatory mediator. DGLA is metabolized to15-hydroxyl DGLA, which blocks the conversion of arachidonic acid to LTs, such as LTB4. In summary,GLA may suppress inflammation through its metabolism to DGLA, which, in turn,cancompetitively inhibit the pro-inflammatory 2-series prostaglandins and 4-series leukotrienes.Theincorporation of GLA and its metabolites in cell membranes may also play a role in the possibleantiinflammatory, anti-thrombotic, anti-atherogenic and anti-proliferative actions of EPO.

Usage in different filed: Dermatology: It has been proved through well controlled clinical study that administration of Prima-1000 significant-ly reduced IGE (the immunoglobulin E responsible in type IV hypersensitivity reactions) in the blood and markedly reduced skin lesions and Pruritus. Prima-1000 is effective in treating skin problemssuch as: >Atopic and allergic Dermatitis. >Chronic Dermatitis &Acne. > Pruritus Racking and inflamed Eczema. > Promotes healthy skin, and nourishes brittle nail and hair. >Psoriasis. > Stevens Johnson Syndrome.

How to use: Atopic & Allergic Dermatitis Adult dosages: In moderate condition 1 cap 2 times daily but in severe position dosage may be increased up to 1cap 3/4 times daily. or as directed by the health care provider. Children dosages: The recommended daily dose of prima-1000 one cap 1/2 times daily with meals for 3/4 months oras advised by the health care provider. Stevens Johnson Syndrome:The usual dose of Prima-1000 with meal or after meal 1 Cap 2 times daily for 15  to 20 days or asadvised by the physicians. Psoriasis: Initially 1cap 2/3 times daily with or after meal. The maintenance dose is 1 cap once over a longperiod or as suggested by the Concerned physician.Premenstrual Syndrome: It has been observed that more than 40% menstruating women are effected bypremenstrual syndrome(PMS), such as abdominal bloating,Headaches, Fatigue, Fluid retention,Pelvic pain, Mood swings, Aggressions, Memory impairment, Insomnia and Anxiety etc. Prima-1000highly effective treatment to eradicate the symptoms of PMS, were attributed to the ability of PGE, toinhibit the affects of prolactin, an agent that responsible for premenstrual syndrome.How to use:Benign Breast diseases & Mastalgia:The recommended daily dose of Prima-1000 one cap 2/3 times daily with or after meal for 3/4months for getting optimum result or as advised by the health care provider.Premenstrual Syndrome (PMS):The recommended daily dose 1cap 2 times daily at morning and night with meal for 3/4 months or asadvised by the health care provider.

Adverse Reactions: EPO may cause gastrointestinal symptoms like nausea, vomiting, flatulence, diarrhoea and bloating.Headaches have also been reported in those taking EPO. It may precipitate symptoms of undiag-nosed complex partial seizures and should be used, if at all,with extreme caution in those with ahistory of seizure disorder or those taking drugs that lower the seizure threshold, such as aliphaticphenothiazines.